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PURPOSE: The reported outcomes of central retinal artery occlusion (CRAO) with or without treatment vary considerably. Although local intra-arterial fibrinolysis (LIF) using recombinant tissue plasminogen activator (rtPA) is a promising treatment, outcomes have not been compared in randomized trials.DESIGN: Prospective randomized multicenter clinical trial (the European Assessment Group ray Ban Aviator for Lysis in the Eye Study) to compare treatment outcome after conservative standard treatment (CST) and LIF for acute nonarteritic CRAO.PARTICIPANTS: Between 2002 and 2007, 9 centers in Austria and Germany recruited 84 patients (40 received CST, 44 received LIF), and data for 82 patients were analyzed.METHODS: Patients (age 18-75 years) with CRAO, symptoms for 20 hours or ray Ban Sunglasses less, and best-corrected visual acuity (BCVA) <0.5 logarithm of the minimum angle of resolution (logMAR) were randomized to the CST or LIF group.MAIN OUTCOME MEASURES: The primary end Ray Ban Switzerland point was BCVA after 1 month; the secondary end point was safety.RESULTS: The ray Ban Clubmaster mean interval between first symptoms and therapy was 10.99+/-5.49 hours (CST) and 12.78+/-5.77 hours (LIF). The mean BCVA (logMAR) improved significantly in both groups (CST: -0.44 [standard deviation 0.55]; LIF: -0.45 [standard deviation 0.55]; both P < 0.0001) and did not differ between groups (P=0.69). Clinically significant visual improvement (> or = 0.3 logMAR) was noted in 60.0% (CST) and 57.1% (LIF) of patients. Two patients in the CST group (4.3%) and 13 patients in the LIF group (37.1%) had adverse reactions. Because of apparently similar ray Ban Wayfarer efficacy and the higher rate of adverse reactions in the LIF group, the study was stopped after the first interim analysis at the recommendation of the data and safety monitoring committee.CONCLUSIONS: In light of these 2 therapies\' similar outcomes and the higher rate of adverse reactions associated with LIF, we cannot recommend LIF for the management of acute CRAO.FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.Copyright 2010 American Academy of Ophthalmology. Published by Elsevier Inc. ray Ban Schweiz All rights reserved.Comment inThrombolysis for artery occlusion. [Ophthalmology. 2011]Thrombolysis for artery occlusion.Arthur A, Aaron S. Ophthalmology. 2011 Mar; 118(3):604; author reply 604-5.


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